DEVELOPMENT AND IN VITRO EVALUATION OF A NEW TOPICAL O/W EMULGEL FROM FRUIT EXTRACT OF PYRUS COMMUNIS
By: Khiljee, Tanzila
.
Contributor(s): Naveed Akhtar.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(4).Description: 75-79p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective
:
The aim of the present study was to develop a new t
opical dosage form containing
Pyrus communis
fruit extract. Developed formulation
was O/W Emulgel which was evaluated by its
in vitro
tests and its stability studies at different stora
ge conditions.
Methods
:
Hydroalcoholic
Pyrus communis
extract was prepared by the maceration process. A
4%
Pyrus communis
emulgel was prepared by the
combination of emulsion and gel at a specific tempe
rature and mixing through homogenizers. The formula
tions having different concentration of
carbopol 940 (gelling agent) were placed at 8 °C, 2
5 °C, 40 °C and 40 °C+75%RH for 3 mo in order to fi
nd out the most stable formulation. After the
selection of final emulgel formulation was eventual
ly further evaluated for
in vitro
studies such as phase separation, centrifugation,
rheology, pH,
conductivity, organoleptic properties and mean drop
let size over a period of 12 w at 8 °C, 25 °C, 40 °
C and 40 °C+75%RH.
Results
:
In vitro
evaluation of the selected
Pyrus communis
emulgel formulation showed good resistance to phas
e separation on centrifugation,
conductivity gradually increases due to oil in wate
r emulgel and pH of formulation was gradually decre
ased. The rheological behavior was non-
Newtonian pseudoplastic and showed shear thinning f
luid behavior. Mean droplet size of
Pyrus communis
emulgel was 16.0±0.20 μm and after 90 d
droplet size was 16.7±0.55 μm at high storage tempe
ratures at 40 °C and 40 °C+75RH and no significant c
hanges were observed at normal storage
conditions at 8 °C and 25 °C.
Conclusion
:
Pyrus communis
emulgel fresh fruit extract showed stable formulat
ion at different storage conditions. This new formu
lation will be a
good addition to pharmaceutical dosage forms made f
rom traditionally used plants.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020912 |
Objective
:
The aim of the present study was to develop a new t
opical dosage form containing
Pyrus communis
fruit extract. Developed formulation
was O/W Emulgel which was evaluated by its
in vitro
tests and its stability studies at different stora
ge conditions.
Methods
:
Hydroalcoholic
Pyrus communis
extract was prepared by the maceration process. A
4%
Pyrus communis
emulgel was prepared by the
combination of emulsion and gel at a specific tempe
rature and mixing through homogenizers. The formula
tions having different concentration of
carbopol 940 (gelling agent) were placed at 8 °C, 2
5 °C, 40 °C and 40 °C+75%RH for 3 mo in order to fi
nd out the most stable formulation. After the
selection of final emulgel formulation was eventual
ly further evaluated for
in vitro
studies such as phase separation, centrifugation,
rheology, pH,
conductivity, organoleptic properties and mean drop
let size over a period of 12 w at 8 °C, 25 °C, 40 °
C and 40 °C+75%RH.
Results
:
In vitro
evaluation of the selected
Pyrus communis
emulgel formulation showed good resistance to phas
e separation on centrifugation,
conductivity gradually increases due to oil in wate
r emulgel and pH of formulation was gradually decre
ased. The rheological behavior was non-
Newtonian pseudoplastic and showed shear thinning f
luid behavior. Mean droplet size of
Pyrus communis
emulgel was 16.0±0.20 μm and after 90 d
droplet size was 16.7±0.55 μm at high storage tempe
ratures at 40 °C and 40 °C+75RH and no significant c
hanges were observed at normal storage
conditions at 8 °C and 25 °C.
Conclusion
:
Pyrus communis
emulgel fresh fruit extract showed stable formulat
ion at different storage conditions. This new formu
lation will be a
good addition to pharmaceutical dosage forms made f
rom traditionally used plants.
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